A virtuous cycle operated by ERp44 and ERGIC-53 guarantees proteostasis in the early secretory compartment
Summary: The composition of the secretome depends on the combined action of cargo receptors that facilitate protein transport and sequential checkpoints that Denim restrict it to native conformers.Acting after endoplasmic reticulum (ER)-resident chaperones, ERp44 retrieves its clients from downstream compartments.To guarantee efficient quality cont